Ultra-high-resolution small- animal SPECT imaging
نویسنده
چکیده
Today the majority of clinical molecular imaging procedures are carried out with single photon emitters and gamma cameras, in planar mode and Single Photon Emission Computed Tomography (SPECT) mode. Thanks to the development of advanced multi-pinhole collimation technologies, SPECT imaging of small experimental animals is rapidly gaining in popularity. Whereas resolutions in routine clinical SPECT are typically larger than one cm (corresponding to >1000 μl), it has recently proved possible to obtain spatial resolutions of about 0.35 mm (≈ 0.04 μl) in the mouse. Meanwhile, SPECT systems that promise an even better performance are under construction. The new systems are able to monitor functions in even smaller structures of the mouse than was possible with dedicated small-animal Positron Emission Tomography (≈ 1 mm resolution corresponding to one μl). This paper provides a
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